中文名称 | (R)-6-(N-(2-氯-4-氟苯基)氨磺酰基)环己-1-烯羧酸乙酯;瑞沙托维 |
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英文名称 | (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate;Resatorvid (Synonyms:TAK-242; CLI-095) |
CAS号 | 243984-11-4 |
分子式 | C15H17ClFNO4S |
分子量 | 361.82 |
外观 | Off-white to yellow solid |
储存条件 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.
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