中文名称 | trans-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐 | Y-27632 二盐酸盐 | (R)-(+)-反式-4-(1-氨基乙基)-N-(4-吡啶基)环己烷甲酰胺 二盐酸盐 |
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英文名称 | Y-27632 Dihydrochloride (Synonyms: Y-27632 2HCl ; trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride) |
CAS号 | 129830-38-2 |
分子式 | C14H21N3O.2HCl |
分子量 | 320.26 | 247.34(free) |
MDL | MFCD03490488 |
外观 | White to off-white powder |
储存条件 | 4°C, sealed storage, away from moisture |
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 2HClis a potent, ATP-competitive inhibitor of ROCKs including p160ROCK (Ki = 140 nM) and ROCK2 (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM. One-hour treatment with 10 µMY-27632 2HCl blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.
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