盐酸多柔比星 | 盐酸阿霉素
Doxorubicin(Adriamycin) Hydrochloride | Doxorubicin HCl
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基本信息
中文名称盐酸多柔比星 | 盐酸阿霉素
英文名称 Doxorubicin(Adriamycin) Hydrochloride | Doxorubicin HCl
CAS号25316-40-9
分子式C27H29NO11.HCl
分子量 579.98
MDLMFCD00077757
外观Orange red powder
储存条件Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
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Doxorubicin is an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.

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