| 中文名称 | 盐酸多柔比星 | 盐酸阿霉素 |
|---|---|
| 英文名称 | Doxorubicin (Adriamycin) Hydrochloride (Synonyms: Doxorubicin (DOX) HCl; Hydroxydaunorubicin hydrochloride; ADR;NSC 123127;Hydroxydaunorubicin HCl ) |
| CAS号 | 25316-40-9 |
| 分子式 | C27H29NO11.HCl |
| 分子量 | 579.98 |
| MDL | MFCD00077757 |
| 外观 | Orange red powder |
| 储存条件 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.
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