中文名称 | 6-((2-((4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)嘧啶-2-基)氨基)乙基)氨基)烟腈; 拉格鲁西布 |
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英文名称 | Laduviglusib (Synonyms: CHIR-99021; CT99021) |
CAS号 | 252917-06-9 |
分子式 | C22H18Cl2N8 |
分子量 | 465.34 |
MDL | MFCD11846251 |
外观 | Off-white to light brown powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
化学稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
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Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.
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