2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制剂II)
RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)
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基本信息
中文名称2-[3-(6-甲基-2-吡啶基)-1H-吡唑-4-基]-1,5-萘啶 (ALK 5抑制剂II)
英文名称 RepSox (Synonyms: E-616452; SJN 2511;ALK5 Inhibitor II)
CAS号446859-33-2
分子式C17H13N5
分子量 287.32
MDL MFCD09037561
外观 Light brown to yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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RepSox (E-616452) is a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (IC50s = 4, 18, and 23 nM for ALK5 autophosphorylation, TGF-β cellular assay, and ALK5 binding in HepG2 cells, respectively). This inhibitor demonstrated less potent activity (IC50s > 16 μM) when tested against a panel of 9 related kinases, including p38 MAPK and GSK3. At 25 μM, this compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription.
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