中文名称 | (E)-4-羟基他莫昔芬 |
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英文名称 | (E)-4-Hydroxytamoxifen; (E)-Afimoxifene |
CAS号 | 174592-47-3 |
分子式 | C26H29NO2 |
分子量 | 387.51 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
Afimoxifene, E-isomer, also called (E)-4-Hydroxytamoxifen, is a SERM and active metabolite of tamoxifen. The E isomer is less active thatn the Z isomer. It induces autophagy, vacuole formation and KRAS degradation in cancerl cells and decreases contractility in myocytes.
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