| 中文名称 | 氨磷汀 |
|---|---|
| 英文名称 | Amifostine (Synonyms: WR2721) |
| CAS号 | 20537-88-6 |
| 分子式 | C5H15N2O3PS |
| 分子量 | 214.22 |
| MDL | MFCD00233058 |
| 外观 | White to off-white powder |
| 储存条件 | Powder -20°C3 years ; 4°C 2 years ;| In solvent -80°C 6 months ; -20°C 1 month |
Amifostine (WR2721) is a potent cytoprotective and radioprotective agent, selectively safeguarding normal tissues from chemotherapy and radiation-induced damage. It acts as a prodrug, activating to WR-1065 by alkaline phosphatase, which scavenges free radicals and protects cells. Amifostine also induces HIF-α1 and p53, key regulators in the cellular response to hypoxia and DNA damage. Its antiangiogenic properties, by modulating VEGF-A, suggest potential in inhibiting tumor vasculature. Recent studies highlight its renal toxicity reduction and explore PEGylation to enhance safety and efficacy, making Amifostine a versatile protector in cancer therapies.
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