中文名称 | 硼替佐米 | 保特佐米 |
---|---|
英文名称 | Bortezomib | PS-341 | LDP-341 | NSC 681239 |
CAS号 | 179324-69-7 |
分子式 | C19H25BN4O4 |
分子量 | 384.24 |
MDL | MFCD09056737 |
外观 | White to off-white solid |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
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