中文名称 | 4-((2-氨基苯基)氨甲酰)苄基氨基甲酸3-吡啶基甲基酯 |
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英文名称 | Entinostat (MS-275; SNDX-275; 恩替诺特 ) |
CAS号 | 209783-80-2 |
分子式 | C21H20N4O3 |
分子量 | 376.41 |
外观 | Yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Entinostat (MS-275, SNDX-275) strongly inhibits HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM in cell-free assays, compared with HDACs 4, 6, 8, and 10. Entinostat induces autophagy and apoptosis.
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