中文名称 | 贝利司他 |
---|---|
英文名称 | Belinostat (Synonyms: PXD101; PX105684; NSC726630; PX-105684) |
CAS号 | 866323-14-0 |
分子式 | C15H14N2O4S |
分子量 | 318.35 |
外观 | Off-white crystalline powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
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Keywords: PXD 101; PXD101; PXD-101; PX105684; PX-105684; PX 105684; NSC726630
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