| 中文名称 | β-拉帕醌;β-拉帕康 |
|---|---|
| 英文名称 | β-Lapachone (Synonyms: Beta-Lapachone; ARQ-501; NSC-26326;ARQ 501;NSC 26326;NSC 629749;SL 11001) |
| CAS号 | 4707-32-8 |
| 分子式 | C15H14O3 |
| 分子量 | 242.27 |
| 外观 | Brown to red powder |
| 储存条件 | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2.
β-Lapachone has been used:
as an anticancer compound in catalase-inhibitable luminol/hydrogen peroxide (HRP)-dependent chemiluminometric assay in Lewis lung carcinoma (LLC) cells and isolated mitochondria
as a naphthoquinone to study its effects on the growth and differentiation of mice granulocyte and macrophage progenitor cells
as a substrate to study the enzyme activity of human recombinant NAD(P)H dehydrogenase 1 (NQO1) protein
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