| 中文名称 | SB-431542 |
|---|---|
| 英文名称 | SB-431542 |
| CAS号 | 301836-41-9 |
| 分子式 | C22H16N4O3 |
| 分子量 | 384.39 |
| 外观 | white to off-white solid powder |
| 储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
SB-431542 is a novel small molecule inhibitor of the type I TGF-beta receptor, on a panel of human malignant glioma cell lines. SB-431542 blocked the phosphorylation and nuclear translocation of the SMADs, intracellular mediators of TGF-beta signaling, with decreased TGF-beta-mediated transcription. Furthermore, SB-431542 inhibited the expression of two critical effectors of TGF-beta-vascular endothelial growth factor and plasminogen activator inhibitor-1.
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