中文名称 | GSK2656157 | GSK-2656157 |
---|---|
英文名称 | GSK2656157 (Synonyms: GSK-2656157) |
CAS号 | 1337532-29-2 |
分子式 | C23H21FN6O |
分子量 | 416.45 |
外观 | Off-white to light yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy.
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