中文名称 | 3-((3R,4R)-4-甲基-3-(甲基(7H-吡咯并[2,3-d]嘧啶-4-基)氨基)哌啶-1-基)-3-氧代丙烷腈 |
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英文名称 | Tofacitinib (Synonyms: Tasocitinib; CP-690550; 托法替尼; 托法替布) |
CAS号 | 477600-75-2 |
分子式 | C16H20N6O |
分子量 | 312.37 |
MDL | MFCD11035919 |
外观 | White or off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.
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