中文名称 | 枸橼酸托法替尼丨枸橼酸托法替布 |
---|---|
英文名称 | Tofacitinib Citrate | Tasocitinib Citrate | CP-690550 Citrate |
CAS号 | 540737-29-9 |
分子式 | C16H20N6O.C6H8O7 |
分子量 | 504.49 |
外观 | White to off-white powder |
储存条件 | 4°C, sealed storage, away from moisture and light |
Tofacitinib, also known as tasocitinib, CP-690550, is a Janus kinase (JAK) inhibitor. Tofacitinib modulates the signaling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. JAK enzymes transmit cytokine signaling through pairing of JAKs (e.g., JAK1/JAK3, JAK1/JAK2, JAK1/TyK2, JAK2/JAK2). Tofacitinib inhibited the in vitro activities of JAK1/JAK2, JAK1/JAK3, and JAK2/JAK2 combinations with IC50 of 406, 56, and 1377 nM, respectively.
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