阿贝西利甲磺酸盐
Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate
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5 mg 10 mg
产品库存
3-5days
目录价格
¥566.00
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产品库存
3-5days
目录价格
¥1066.00
会员价格
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- +
基本信息
中文名称阿贝西利甲磺酸盐
英文名称 Abemaciclib Mesylate | LY2835219 Mesylate) | Abemaciclib Methanesulfonate
CAS号1231930-82-7
分子式C28H36F2N8O3S
分子量602.70
外观White to yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
安全信息
产品详情

Abemaciclib, also known as LY2835219, is orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 inhibits CDK4 and CDK6 with low nanomolar potency. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth.


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