维兰特罗三苯乙酸盐
Vilanterol Trifenatate (Synonyms: Vilanterol Trifenate; GW642444 trifenatate)
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基本信息
中文名称维兰特罗三苯乙酸盐
英文名称 Vilanterol Trifenatate (Synonyms: Vilanterol Trifenate; GW642444 trifenatate)
CAS号503070-58-4
分子式C44H49Cl2NO7
分子量774.77
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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 Vilanterol, also known as GW-642444, is a long-acting beta-2 agonist. It selectively induces cAMP accumulation in CHO cells expressing the β2-AR over the β1- and β3-ARs (EC50s = 0.4, 398, and 794 nM for the human receptors, respectively). Vilanterol inhibits contractions induced by electrical stimulation in isolated superfused guinea pig trachea strips. It inhibits bronchospasms induced by histamine. Formulations containing vilanterol, in combination with fluticasone, have been used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma.

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