中文名称 | 碘苷; 5-碘-2'-脱氧尿苷 |
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英文名称 | Idoxuridine (5-IUdR,5-Iodo-2′-deoxyuridine); 5-I-2’-dU; 5-Iodo-2’-Deoxyuridine |
CAS号 | 54-42-2 |
分子式 | C9H11IN2O5 |
分子量 | 354.10 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Idoxuridine is an anti-herpesvirus antiviral and anticancer drug. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing. It is used only topically due to cardiotoxicity. It was synthesized by William Prusoff in the late 1950s. Initially developed as an anticancer drug, idoxuridine became the first antiviral agent in 1962.
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