| 中文名称 | 熊去氧胆酸; 3alpha,7beta-二羟基-5beta-胆甾烷-24-酸 |
|---|---|
| 英文名称 | Ursodeoxycholic acid (Synonyms:Ursodeoxycholate; Ursodiol; UDCA;3,7-Dihydroxycholan-24-oic acid; 3alpha,7beta-Dihydroxy-6beta-cholan-24-oic acid) |
| CAS号 | 128-13-2 |
| 分子式 | C24H40O4 |
| 分子量 | 392.57 |
| 外观 | White Powder |
| 储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active.
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