中文名称 | Inavolisib | GDC-0077 |
---|---|
英文名称 | Inavolisib | GDC-0077 | RG6114 | RO-7113755 |
CAS号 | 2060571-02-8 |
分子式 | C18H19F2N5O4 |
分子量 | 407.37 |
外观 | White to yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutant versus wild-type PI3Kα.
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