Nedisertib (M3814)
Nedisertib (Synonyms: Peposertib; M3814; MSC2490484A)
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中文名称Nedisertib (M3814)
英文名称 Nedisertib (Synonyms: Peposertib; M3814; MSC2490484A)
CAS号1637542-33-6
分子式C24H21ClFN5O3
分子量481.91
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Nedisertib (Peposertib) is an orally active selective DNA-dependent protein kinase (DNA-PK) inhibitor with an IC50 value of less than 3 nM. Nedisertib also acts as a modulator of ABCG2, capable of reversing ABCG2-mediated multidrug resistance (MDR), thus providing new strategies for combination therapy. By inhibiting DNA double-strand break repair, Nedisertib can enhance the efficacy of chemotherapy and radiotherapy. Nedisertib exhibits antitumor activity.
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