中文名称 | (R)-3-(甲氨基)-2,3,4,9-四氢-1H-咔唑-6-甲酰胺琥珀酸盐水合物;琥珀酸夫罗曲坦一水合物; 夫罗曲坦琥珀酸盐;罗曲普坦琥珀酸盐;琥珀酸福伐曲坦 |
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英文名称 | Frovatriptan Succinate Monohydrate (Synonyms: Frovatriptan succinate hydrate;(R)-Frovatriptan succinate hydrate; SB 209509 succinate hydrate; VML 251 succinate hydrate) |
CAS号 | 158930-17-7 |
分子式 | C18H25N3O6 |
分子量 | 379.41 |
MDL | MFCD18251278 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Frovatriptan Succinate is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity. It is agonist of 5-HT1B/1D receptors. Frovatriptan succinate binds selectively and with high affinity to 5-HT 1B and presynaptic 5-HT 1D receptors in the extracerebral and intracranial arteries. This leads to an inhibition of serotonin activity and results in vasoconstriction of the painfully dilated blood vessels during migraine attack. Frovatriptan succinate is indicated for the acute treatment of migraine.
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