中文名称 | 阿培利司盐酸盐 |
---|---|
英文名称 | Alpelisib hydrochloride |
CAS号 | 1584128-91-5 |
分子式 | C19H23ClF3N5O2S |
分子量 | 477.93 |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively. Alpelisib hydrochloride (BYL-719 hydrochloride) shows antineoplastic activity.
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