中文名称 | GSK2126458 |
---|---|
英文名称 | Omipalisib | GSK2126458 | GSK458 |
CAS号 | 1086062-66-9 |
分子式 | C25H17F2N5O3S |
分子量 | 505.50 |
外观 | Off-white to yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy.
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