中文名称 | MMAF hydrochloride |
---|---|
英文名称 | MMAF Hydrochloride;Monomethylauristatin F Hydrochloride |
CAS号 | 1415246-68-2 |
分子式 | C39H66ClN5O8 |
分子量 | 768.42 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Monomethyl auristatin F (MMAF) HCl is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. Mafodotin is the term used in International Nonproprietary Names for MMAF-antibody-conjugates to describe MMAF along with its antibody-binding structure. As opposed to auristatin F, which has two methyl substituents in its N-terminal amino group, MMAF is actually desmethyl-auristatin F.
© 2020-2024 凯立德生物医药技术(上海)有限公司 版权所有
沪ICP备15046197号-3
沪公网安备31011502007856号
Designed by Kuanersoft