| 中文名称 | 常山酮; 卤夫酮; 溴氯哌喹酮 |
|---|---|
| 英文名称 | Halofuginone (Synonyms: Tempostatin; RU-19110) |
| CAS号 | 55837-20-2 |
| 分子式 | C16H17BrClN3O3 |
| 分子量 | 414.68 |
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
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