成球菌素
Conglobatin
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选择规格
1 mg 5 mg
产品库存
3-5days
目录价格
¥2500.00
会员价格
产品库存
3-5days
目录价格
¥7500.00
会员价格
选择数量
- +
基本信息
中文名称成球菌素
英文名称 Conglobatin
CAS号72263-05-9
分子式C28H38N2O6
分子量498.61
外观White to grayish white powder
储存条件Store at -20°C
安全信息
产品详情

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus. It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells. It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 uM, respectively) and decreases the number of invasive cells in vitro. When combined with lapatinib , tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone. Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 uM). It also inhibits β1 integrin activation leading to a loss of cellular adhesion.

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