中文名称 | 利克飞龙 |
---|---|
英文名称 | Licofelone |
CAS号 | 156897-06-2 |
分子式 | C23H22ClNO2 |
分子量 | 379.88 |
外观 | Off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Licofelone (ML3000, Compound 3e) is a dual inhibitor of COX and 5-lipoxygenase (5-LOX) with IC50 of 0.21 μM and 0.18 μM, respectively. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins. Licofelone is considered as a treatment for osteoarthritis.
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