5-[6-[4-(1-哌嗪基)苯基]吡唑并[1,5-a]嘧啶-3-基]喹啉
LDN-212854 | BMP Inhibitor III | LDN 212854 | 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
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基本信息
中文名称5-[6-[4-(1-哌嗪基)苯基]吡唑并[1,5-a]嘧啶-3-基]喹啉
英文名称 LDN-212854 | BMP Inhibitor III | LDN 212854 | 5-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
CAS号1432597-26-6
分子式C25H22N6
分子量406.48
外观Light yellow to yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM). LDN-212854 also inhibits ALK1 (IC50: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC).


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PMID: 23547776 PMCID: PMC3901569 DOI: 10.1021/cb300655w
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