替格鲁西布 | 泰格列净
Tideglusib (Synonyms: NP031112; NP-12)
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中文名称替格鲁西布 | 泰格列净
英文名称 Tideglusib (Synonyms: NP031112; NP-12)
CAS号865854-05-3
分子式C19H14N2O2S
分子量334.39
外观White to off-white powder
储存条件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Tideglusib, also known as NP031112, is a GSK-3 inhibitor, which is currently under clinical trial for Alzheimer's disease. Tideglusib protects neural stem cells against NMDA receptor overactivation. Tideglusib reduces progression of brain atrophy in progressive supranuclear palsy in a randomized trial. Tideglusib prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.

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