中文名称 | (S)-N-(4-((3-氯-4-氟苯基)氨基(S)-N-(4-((3-四氢呋喃-3-基)氧基)喹唑啉-6-基)-4-(二甲基氨基)丁-2-烯酰胺 |
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英文名称 | (E/Z)-Afatinib (Synonyms: (E/Z)-BIBW 2992; (S)-阿法替尼) |
CAS号 | 439081-18-2 |
分子式 | C24H25ClFN5O3 |
分子量 | 485.94 |
外观 | White to off-white powder |
储存条件 | 4°C, protect from light |
(E/Z)-Afatinib ((E/Z)-BIBW 2992) is the mixture of (E)-Afatinib and (Z)-Afatinib. Afatinib (HY-10261) is an irreversible inhibitor of EGFR, by irreversibly binding to their ATP binding site to block activation of EGFR, HER2, HER4, and EGFRvIII. Afatinib used in co-administration with Temozolomide (HY-17364), potently targeting to EGFRvIII-cMet signaling in glioblastoma cells.
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