中文名称 | 1-(3-(叔丁基)-1-(对甲苯基)-1H-吡唑-5-基)-3-(4-(2-吗啉乙氧基)萘-1-基)脲; 达马莫德;度马莫德 |
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英文名称 | Doramapimod (Synonyms: BIRB 796) |
CAS号 | 285983-48-4 |
分子式 | C31H37N5O3 |
分子量 | 527.66 |
MDL | MFCD09752957 |
外观 | Off-white to gray powder |
储存条件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
Doramapimod (BIRB 796) is an orally active, potent inhibitor of p38 MAPK with IC50 values of p38α=38 nM, p38β=65 nM, p38γ=200 nM, and p38δ=520 nM. Doramapimod exhibits picomolar affinity (Kd=0.1 nM) for p38 kinase. Doramapimod also inhibits B-Raf and Abl with IC50 values of 83 nM and 14.6 μM, respectively.
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