中文名称 | 帕唑帕尼 |
---|---|
英文名称 | Pazopanib | GW786034 |
CAS号 | 444731-52-6 |
分子式 | C21H23N7O2S |
分子量 | 437.52 |
外观 | White powder |
储存条件 | Store in a tightly closed container in a cool and dry place |
Pazopanib(GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.An oral angiogenesis inhibitor targeting VEGFR and PDGFR.A potent and selective inhibitor of tyrosine kinases, targeting VEGFR/c-KIT/PDGFR, blocking angiogenesis; as an oral antineoplastic agent.
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