中文名称 | 阿那曲唑; 阿纳托唑 |
---|---|
英文名称 | Anastrozole |
CAS号 | 120511-73-1 |
分子式 | C17H19N5 |
分子量 | 293.37 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Anastrozole (formerly known as ZD-1033) is a potent, third-generation nonsteroidal and selective inhibitor of aromatase with an IC50 of 15 nM for inhibiting human placental aromatase. Anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast. Anastrozole has been reported to inhibit human placental aromatase with an IC50 value of 14.6 nM or 0.0043μg/ml.
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