中文名称 | 依托考昔 |
---|---|
英文名称 | Etoricoxib (MK-663; MK-0663) |
CAS号 | 202409-33-4 |
分子式 | C18H15ClN2O2S |
分子量 | 358.84 |
外观 | Light yellow to yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Etoricoxib (also known as MK-0663) is a non-steroidal anti-inflammatory drgu (NSAID) which acts as a selective and orally bioactive COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. Etoricoxib is a synthetic NSAID with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib binds specifically to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
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