中文名称 | Adezmapimod Hydrochloride | SB 203580 Hydrochloride | RWJ 64809 Hydrochloride |
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英文名称 | Adezmapimod Hydrochloride (Synonyms: SB 203580 hydrochloride; RWJ 64809 hydrochloride) |
CAS号 | 869185-85-3 |
分子式 | C21H17ClFN3OS |
分子量 | 413.90 |
外观 | Light yellow to yellow powder |
储存条件 | 4°C, sealed storage, away from moisture |
Adezmapimod (SB 203580; RWJ 64809) hydrochloride is a selective and ATP-competitive p38 MAPK inhibitor with IC50s of 50 nM and 500 nM for SAPK2a/p38 and SAPK2b/p38β2, respectively. Adezmapimod hydrochloride inhibits LCK, GSK3β and PKBα with IC50s of 100-500-fold higher than that for SAPK2a/p38. Adezmapimod hydrochloride does not disrupt JNK activity and is an autophagy and mitophagy activator.
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