中文名称 | 蒽[1,9-cd]吡唑-6(2H)-酮; 1,9-吡唑蒽酮; 吡唑并蒽酮 |
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英文名称 | SP600125 (Synonyms: Nsc75890; SP 600125; Anthra[1,9-cd]pyrazol-6(2H)-one;1,9-Pyrazoloanthrone; Anthrapyrazolone) |
CAS号 | 129-56-6 |
分子式 | C14H8N2O |
分子量 | 220.23 |
MDL | MFCD00022289 |
SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis.
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