中文名称 | SNX 2112 | PF-04928473 |
---|---|
英文名称 | SNX 2112 | PF-04928473 |
CAS号 | 908112-43-6 |
分子式 | C23H27F3N4O3 |
分子量 | 464.48 |
外观 | White to off-white powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
SNX-2112, also known as PF 04928473, is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials. In all cell lines, SNX-2112 led to degradation of MET, HER-2, EGFR, and AKT as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT signaling, followed by complete cell cycle arrest.
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