中文名称 | 2-(5,6-二甲基-9-氧代-9H-氧杂蒽-4-基)乙酸; 5,6-二甲基呫吨酮-4-乙酸; 2,5-己酮可可碱;伐地美生 |
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英文名称 | Vadimezan (Synonyms: DMXAA; ASA-404) |
CAS号 | 117570-53-3 |
分子式 | C17H14O4 |
分子量 | 282.29 |
MDL | MFCD00870555 |
外观 | Light brown powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Vadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.
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