2-(5,6-二甲基-9-氧代-9H-氧杂蒽-4-基)乙酸; 5,6-二甲基呫吨酮-4-乙酸; 2,5-己酮可可碱;伐地美生
Vadimezan (Synonyms: DMXAA; ASA-404; 5,6-Dimethylxanthenone-4-acetic Acid)
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中文名称2-(5,6-二甲基-9-氧代-9H-氧杂蒽-4-基)乙酸; 5,6-二甲基呫吨酮-4-乙酸; 2,5-己酮可可碱;伐地美生
英文名称 Vadimezan (Synonyms: DMXAA; ASA-404; 5,6-Dimethylxanthenone-4-acetic Acid)
CAS号117570-53-3
分子式C17H14O4
分子量282.29
MDLMFCD00870555
外观Light brown powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Vadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.
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