中文名称 | (1S,4S,7Z,10S,16E,21R)-7-亚乙基-4,21-二异丙基-2-氧杂-12,13-二硫杂-5,8,20,23-四氮杂双环[8.7.6]二十三烷-16-烯-3,6,9,19,22-五酮; 罗米地辛 |
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英文名称 | Romidepsin (Synonyms: FK 228; FR 901228; NSC 630176) |
CAS号 | 128517-07-7 |
分子式 | C24H36N4O6S2 |
分子量 | 540.70 |
MDL | MFCD18433404 |
外观 | White to off-white powder |
Romidepsin (FR 901228) is an HDAC inhibitor targeting HDAC1/2/4/6 with IC50 values of 36/47/510/1400 nM. It has antitumor activity and is used to treat peripheral and cutaneous T-cell lymphomas.Romidepsin (FK 228), derived from Chromobacterium violaceum, induces G2/M cell cycle arrest and apoptosis.
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