中文名称 | (4R,5S,6S)-3-(((3S,5S)-5-(二甲基氨基甲酰基)吡咯烷-3-基)硫基)-6-((R)-1-羟乙基)-4-甲基-7- 氧代-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸三水合物; 美罗培南三水合物 |
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英文名称 | Meropenem Trihydrate (Synonyms: SM 7338 trihydrate) |
CAS号 | 119478-56-7 |
分子式 | C17H31N3O8S |
分子量 | 437.51 |
MDL | MFCD08600005 |
外观 | White or yellowish crystalline powder |
Meropenem is a carbapenem antibiotic. It is active against clinical isolates of Gram-positive and Gram-negative bacteria in vitro, including S. pneumoniae, H. influenzae, N. gonorrhoeae, E. coli, P. aeruginosa, C. difficile, and methicillin-susceptible and -resistant S. aureus (MICs = ≤0.008-8 μg/ml). It is protective against S. aureus, S. pneumoniae, E. coli, S. marcescens, P. mirabilis, and P. aeruginosa infections in mice with 50% protective dose (PD50) values of 0.13, 0.01, 0.04, 0.07, 0.84, and 0.46 mg/kg, respectively. Formulations containing meropenem have been used in the treatment of a variety of bacterial infections.
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