| 中文名称 | 3-((4-溴-2,6-二氟苄基)氧基)-5-(3-(4-(吡咯烷-1-基)丁基)脲基)异噻唑-4-甲酰胺 |
|---|---|
| 英文名称 | CP-547632 (Synonyms: PAN-90806; CP-632; OSI-632) |
| CAS号 | 252003-65-9 |
| 分子式 | C20H24BrF2N5O3S |
| 分子量 | 532.40 |
| MDL | MFCD07772279 |
| 外观 | White to light yellow powder |
| 储存条件 | 4°C, stored under nitrogen |
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective, with higher selectivity for VEGFR2 and bFGF than for EGFR, PDGFRβ and related tyrosine kinases (TKs). PDGFRβ and related tyrosine kinases (TKs) CP-547632 has antitumour activity.
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