中文名称 | 两性霉素 B |
---|---|
英文名称 | Amphotericin B | NSC 527017 | LNS-AmB |
CAS号 | 1397-89-3 |
分子式 | C47H73NO17 |
分子量 | 924.09 |
外观 | Yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Amphotericin B (AMB, NSC 527017) is an amphipathic polyene antibiotic which permeabilizes ergosterol-containing membranes.
Amphotericin B binds ergosterol and induces membrane pore formations, increasing ROS and suppressing fungal growth. It also increases expression of IL-1-beta, TNF-alpha, BDNF and GDNF and protects against prion-induced neurodegeneration.
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