吉西他滨
Gemcitabine Base | LY 188011 | NSC 613327
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500 mg 1 g
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In-stock
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¥578.00
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In-stock
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¥858.00
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基本信息
中文名称吉西他滨
英文名称 Gemcitabine Base | LY 188011 | NSC 613327
CAS号95058-81-4
分子式C9H11F2N3O4
分子量263.2
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

Gemcitabine (formerly LY-188011, NSC-613327; LY188011, NSC613327; dFdC; dFdCyd; trade name: Gemzar), an approved antimetabolite anticancer drug, is a potent DNA synthesis inhibitor with potential antineoplastic activity. With IC50s of 50 nM, 40 nM, 18 nM, and 12 nM, respectively, it suppresses the growth of PANC1, MIAPaCa2, BxPC3, and Capan2 cells. Difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP) are the active metabolites of gemcitabine that are produced intracellularly. The deoxynucleotide pool available for DNA synthesis is reduced when dFdCDP inhibits ribonucleotide reductase.

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吉西他滨