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盐酸吉西他滨

Gemcitabine Hydrochloride (Synonyms: Gemcitabine HCl; LY 188011 hydrochloride;NSC 613327 HCl)

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产品编号：CL1996A

CAS No.：122111-03-9

MDLNo：

分子式：C₉H₁₂ClF₂N₃O₄

分子量：299.66

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基本信息

中文名称	盐酸吉西他滨
英文名称	Gemcitabine Hydrochloride (Synonyms: Gemcitabine HCl; LY 188011 hydrochloride;NSC 613327 HCl)
CAS号	122111-03-9
分子式	C₉H₁₂ClF₂N₃O₄
分子量	299.66
外观	White to off-white powder
储存条件	4°C, sealed storage, away from moisture and light

安全信息

产品详情

Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate and the active di- and triphosphate forms.It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models. Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma. Formulations containing gemcitabine have been used in the treatment of cancer.
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