中文名称 | 盐酸吉西他滨 |
---|---|
英文名称 | Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl |
CAS号 | 122111-03-9 |
分子式 | C₉H₁₂ClF₂N₃O₄ |
分子量 | 299.66 |
外观 | White to off-white powder |
储存条件 | 4°C, sealed storage, away from moisture and light |
Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate and the active di- and triphosphate forms.It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models. Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma. Formulations containing gemcitabine have been used in the treatment of cancer.
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