中文名称 | 6alpha-乙基-23(S)-甲基胆酸 |
---|---|
英文名称 | INT-777 | S-EMCA | INT 777 |
CAS号 | 1199796-29-6 |
分子式 | C27H46O5 |
分子量 | 450.65 |
外观 | White to yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats.
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