中文名称 | N-(3,3-二甲基吲哚啉-6-基)-2-((吡啶-4-基甲基)氨基)烟酰胺 |
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英文名称 | Motesanib (Synonyms: AMG 706;莫替沙尼 ) |
CAS号 | 453562-69-1 |
分子式 | C22H23N5O |
分子量 | 373.45 |
MDL | MFCD10567689 |
外观 | White to khaki powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Motesanib (AMG 706) is an orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation.
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