| 中文名称 | 司他生坦钠 | 西他塞坦钠 |
|---|---|
| 英文名称 | Sitaxsentan sodium (Synonyms: IPI 1040 sodium; TBC11251 sodium) |
| CAS号 | 210421-74-2 |
| 分子式 | C18H14ClN2NaO6S2 |
| 分子量 | 476.89 |
| 外观 | Light yellow to yellow powder |
| 储存条件 | 4°C, sealed storage, away from moisture |
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally activeendothelin A receptor (ETA) antagonist with an IC50 of 1.4 nM and a Ki of 0.43 nM. Sitaxsentan sodium exhibits an IC50 for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium inhibits ET-1-induced phosphoinositide turnover. Sitaxsentan sodium can significantly alleviate pulmonary arterial hypertension (PAH) symptoms. Sitaxsentan sodium can be used for the study of PAH.
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