伯舒替尼
Bosutinib(SKI-606)
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基本信息
中文名称伯舒替尼
英文名称 Bosutinib(SKI-606)
CAS号380843-75-4
分子式C26H29Cl2N5O3
分子量530.45
外观White to light yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy

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