中文名称 | (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-羟基-5,6-二甲基庚-3-烯-2-基)-7-甲基八氢-4H-茚-4-亚基)亚乙基)环己烷-1,3-二醇 ;帕立骨化醇 |
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英文名称 | Paricalcitol |
CAS号 | 131918-61-1 |
分子式 | C27H44O3 |
分子量 | 416.64 |
MDL | MFCD08067734 |
外观 | White to off-white powder |
储存条件 | 4°C, protect from light, stored under nitrogen |
Paricalcitol, a selective VDR agonist, effectively suppresses PTH mRNA and inhibits parathyroid cell growth, treating secondary hyperparathyroidism in CKD. It's also associated with lower morbidity and improved survival rates compared to other VDRAs, with a favorable side-effect profile. Additionally, paricalcitol exhibits anti-inflammatory effects, potentially beneficial in managing CKD-related inflammation.
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